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September 27 marks the centennial of the most famous equation in the world: E=mc². On this day in 1905, Albert Einstein submitted the paper that laid out the formula. We hear archive tape, and physicist John Rigden, author of Einstein 1905: The Standard of Greatness, explains the seminal formula.

Pain management is the latest target of software developers: Researchers are creating and testing interactive games designed to help young patients cope with discomfort.

Don Adams, known for TV eternity as Agent 86 on the 1960s series Get Smart!, has died at age 82. Adams played Maxwell Smart, a clueless secret agent who puzzled villains and his boss with his confusing explanations and farcical combat style.

Following a Monday briefing on Hurricane Rita's effect on the oil and natural gas infrastructure along the Gulf Coast, President Bush says he is willing to use the nation's strategic petroleum reserves to make up for any shortages caused by hurricane damage.

Immigration is not rising inexorably, but instead mirrors the U.S. business cycle, rising and falling with U.S. demand for workers, a new report from the Pew Hispanic Center argues. Underlying the debate is a more fundamental question: Does immigration satisfy the needs of a healthy economy or undermine it?

A new book on Abraham Lincoln explores how the young Illinois lawyer went on to become president despite suffering from lifelong depression.

John Fogerty — once lead singer of Credence Clearwater Revival and now a solo artist — has buried the hatchet with his record label. The result is a new greatest hits CD called The Long Road Home.

The study makes use of lunar soil samples collected from Apollo 11, 12 and 17.

At least 2,000 U.S. forces have been killed in Iraq since the United States invaded the country two and a half years ago. With the support of a majority of Americans waning, many Senate Democrats are reconsidering their votes to authorize President Bush's military action in Iraq -- an issue that continues to split the party.

The center of New Orleans has plenty of broken windows and flying debris, but it is largely empty of people, as Hurricane Katrina makes its way inland. The system came ashore as a Category Four storm Monday morning east of New Orleans.